Publications

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2012
Wyrwoll CS, Kerrigan D, Holmes MC, Seckl JR, Drake AJ. Altered placental methyl donor transport in the dexamethasone programmed rat. Placenta. 2012;33(3):220-3. Abstract
Cottrell EC, Holmes MC, Livingstone DE, Kenyon CJ, Seckl JR. Reconciling the nutritional and glucocorticoid hypotheses of fetal programming. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012. Abstract
2010
Holmes MC, Carter RN, Noble J, Chitnis S, Dutia A, Paterson JM, et al. 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments. J Neurosci. 2010;30(20):6916-20. Abstract
O’Regan D, Kenyon CJ, Seckl JR, Holmes MC. Environmental disturbance confounds prenatal glucocorticoid programming experiments in Wistar rats. Laboratory animals. 2010;44:199-205. Abstract
Sheward JW, Naylor E, Knowles-Barley S, Armstrong DJ, Brooker GA, Seckl JR, et al. Circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei: behavioral effects are more significant than direct outputs. PloS one. 2010;5:e9783. Abstract
2009
Carter RN, Paterson JM, Tworowska U, Stenvers DJ, Mullins JJ, Seckl JR, et al. Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent. J Neuroendocrinol. 2009;21(11):879-87. Abstract
Wyrwoll CS, Seckl JR, Holmes MC. Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice. Endocrinology. 2009;150(3):1287-93. Abstract
Kimura A, Stevenson PL, Carter RN, MacColl G, French KL, Paul Simons J, et al. Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity. Eur J Neurosci. 2009;30(2):299-306. Abstract
Hartley PS, Sheward J, Scholefield E, French K, Horn JM, Holmes MC, et al. Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes. British journal of haematology. 2009;146:185-92. Abstract
2008
Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein DG, Owen E, et al. Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008;22:3896-907. Abstract
Simoncic M, Horvat S, Stevenson PL, Bünger L, Holmes MC, Kenyon CJ, et al. Divergent physical activity and novel alternative responses to high fat feeding in polygenic fat and lean mice. Behavior genetics. 2008;38:292-300. Abstract
Hartley PS, John Sheward W, French K, Horn JM, Holmes MC, Harmar AJ. Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesis. Journal of thrombosis and haemostasis : JTH. 2008;6:1144-52. Abstract
2007
Paterson JM, Holmes MC, Kenyon CJ, Carter R, Mullins JJ, Seckl JR. Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11beta-hydroxysteroid dehydrogenase type 1-deficient mice. Endocrinology. 2007;148:961-6. Abstract
Sheward JW, Maywood ES, French KL, Horn JM, Hastings MH, Seckl JR, et al. Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice. J Neurosci. 2007;27(16):4351-8. Abstract
de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, et al. Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function. The Journal of clinical investigation. 2007;117:1058-67. Abstract
2006
Holmes MC, Sangra M, French KL, Whittle IR, Paterson J, Mullins JJ, et al. 11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids. Neuroscience. 2006;137:865-73. Abstract
Holmes MC, Abrahamsen CT, French KL, Paterson JM, Mullins JJ, Seckl JR. The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. J Neurosci. 2006;26(14):3840-4. Abstract
2005
Nuber UA, Kriaucionis S, Roloff TC, Guy J, Selfridge J, Steinhoff C, et al. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Human molecular genetics. 2005;14:2247-56. Abstract
2004
O’Regan D, Kenyon CJ, Seckl JR, Holmes MC. Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology. American journal of physiology. Endocrinology and metabolism. 2004;287:E863-70. Abstract
Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, et al. Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:7088-93. Abstract
Somponpun SJ, Holmes MC, Seckl JR, Russell JA. Modulation of oestrogen receptor-beta mRNA expression in rat paraventricular and supraoptic nucleus neurones following adrenal steroid manipulation and hyperosmotic stimulation. Journal of neuroendocrinology. 2004;16:472-82. Abstract
Justesen J, Mosekilde L, Holmes M, Stenderup K, Gasser J, Mullins JJ, et al. Mice deficient in 11beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation. Endocrinology. 2004;145:1916-25. Abstract
Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes. 2004;53:931-8. Abstract
2003
Holmes MC, Yau JL, Kotelevtsev Y, Mullins JJ, Seckl JR. 11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles. Annals of the New York Academy of Sciences. 2003;1007:357-66. Abstract
Shinoda J, McLaughlin KE, Bell HS, Swaroop GR, Yamaguchi S-, Holmes MC, et al. Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells. Glia. 2003;42:68-76. Abstract