Publications

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A
Dobkin-Bekman M, Naidich M, Pawson AJ, Millar RP, Seger R, Naor Z. Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent. Mol Cell Endocrinol. 2006;252(1-2):184-90. Abstract
B
Morgan K, Sellar R, Pawson AJ, Lu Z-, Millar RP. Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated. Endocrinology. 2006;147(11):5041-51. Abstract
C
Pfleger KD, Pawson AJ, Millar RP. Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations. Endocrinology. 2008;149(6):3118-29. Abstract
Davidson L, Pawson AJ, Millar RP, Maudsley S. Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor. J Biol Chem. 2004;279(3):1980-93. Abstract
D
Millar RP, Pawson AJ, Morgan K, Rissman EF, Lu Z-. Diversity of actions of GnRHs mediated by ligand-induced selective signaling. Front Neuroendocrinol. 2008;29(1):17-35. Abstract
E
Naidich M, Shterntal B, Furman R, Pawson AJ, Jabbour HN, Morgan K, et al. Elucidation of mechanisms of the reciprocal cross talk between gonadotropin-releasing hormone and prostaglandin receptors. Endocrinology. 2010;151(6):2700-12. Abstract
Barran PE, Roeske RW, Pawson AJ, Sellar R, Bowers MT, Morgan K, et al. Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity. J Biol Chem. 2005;280(46):38569-75. Abstract
G
López de Maturana R, Martin B, Millar RP, Brown P, Davidson L, Pawson AJ, et al. GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells. Neuromolecular Med. 2007;9(3):230-48. Abstract
Maudsley S, Davidson L, Pawson AJ, Chan R, López de Maturana R, Millar RP. Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor. Cancer Res. 2004;64(20):7533-44. Abstract
López de Maturana R, Pawson AJ, Lu Z-, Davidson L, Maudsley S, Morgan K, et al. Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling. Mol Endocrinol. 2008;22(7):1711-22. Abstract
Maudsley S, Davidson L, Pawson AJ, Freestone SH, López de Maturana R, Thomson AA, et al. Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5. Neuroendocrinology. 2006;84(5):285-300. Abstract
Millar RP, Lu Z-, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. Gonadotropin-releasing hormone receptors. Endocr Rev. 2004;25(2):235-75. Abstract
Davidson L, Pawson AJ, López de Maturana R, Freestone SH, Barran P, Millar RP, et al. Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src. J Biol Chem. 2004;279(12):11906-16. Abstract
I
Ubuka T, Morgan K, Pawson AJ, Osugi T, Chowdhury VS, Minakata H, et al. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS ONE. 2009;4(12):e8400. Abstract
Shacham S, Cheifetz MN, Fridkin M, Pawson AJ, Millar RP, Naor Z. Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling. J Biol Chem. 2005;280(32):28981-8. Abstract
Pawson AJ, Maudsley S, Morgan K, Davidson L, Naor Z, Millar RP. Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment. Endocrinology. 2005;146(6):2639-49. Abstract
K
Millar RP, Roseweir AK, Tello JA, Anderson RA, George JT, Morgan K, et al. Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Brain Res. 2010;1364:81-9. Abstract
Ramaesh T, Logie JJ, Roseweir AK, Millar RP, Walker BR, Hadoke PW, et al. Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro. Endocrinology. 2010;151(12):5927-34. Abstract
M
Pawson AJ, Faccenda E, Maudsley S, Lu Z-, Naor Z, Millar RP. Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization. Endocrinology. 2008;149(3):1415-22. Abstract
Pawson AJ, Maudsley SR, Lopes J, Katz AA, Sun Y-, Davidson JS, et al. Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical. Endocrinology. 2003;144(9):3860-71. Abstract
N
Gardner S, Maudsley S, Millar RP, Pawson AJ. Nuclear stabilization of beta-catenin and inactivation of glycogen synthase kinase-3beta by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope. Mol Endocrinol. 2007;21(12):3028-38. Abstract
O
Millar RP, Pawson AJ. Outside-in and inside-out signaling: the new concept that selectivity of ligand binding at the gonadotropin-releasing hormone receptor is modulated by the intracellular environment. Endocrinology. 2004;145(8):3590-3.
P
Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology. 2008;149(11):5811-21. Abstract
Maudsley S, Naor Z, Bonfil D, Davidson L, Karali D, Pawson AJ, et al. Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene. Mol Endocrinol. 2007;21(5):1216-33. Abstract
R
Naor Z, Jabbour HN, Naidich M, Pawson AJ, Morgan K, Battersby S, et al. Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion. Mol Endocrinol. 2007;21(2):524-37. Abstract