Publications

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2013
Brunton PJ, Sullivan KM, Kerrigan D, Russell JA, Seckl JR, Drake AJ. Sex-specific effects of prenatal stress on glucose homeostasis and peripheral metabolism in rats. J Endocrinol. 2013. Abstract
Brunton PJ, Sullivan KM, Kerrigan D, Russell JA, Seckl JR, Drake AJ. Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats. J Endocrinol. 2013;217(2):161-73. Abstract
2012
Reynolds RM, Seckl JR. Antenatal glucocorticoid treatment: are we doing harm to term babies? J Clin Endocrinol Metab. 2012;97(10):3457-9.
Wyrwoll CS, Kerrigan D, Holmes MC, Seckl JR, Drake AJ. Altered placental methyl donor transport in the dexamethasone programmed rat. Placenta. 2012;33(3):220-3. Abstract
Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, et al. Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge. Biological psychiatry. 2012. Abstract
Coutinho AE, Gray M, Brownstein DG, Salter DM, Sawatzky DA, Clay S, et al. 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. Endocrinology. 2012;153(1):234-40. Abstract
Labad J, Price JF, Strachan MW, Fowkes GF, Deary IJ, Seckl JR, et al. Leptin levels and depressive symptoms in people with type 2 diabetes: the edinburgh type 2 diabetes study. Psychosom Med. 2012;74(1):39-45. Abstract
Cottrell EC, Holmes MC, Livingstone DE, Kenyon CJ, Seckl JR. Reconciling the nutritional and glucocorticoid hypotheses of fetal programming. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012. Abstract
Turban S, Liu X, Ramage L, Webster SP, Walker BR, Dunbar DR, et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism that Prevents High Fat Diet-Induced β-Cell Failure. Diabetes. 2012. Abstract
Michailidou Z, Turban S, Miller E, Zou X, Schrader J, Ratcliffe PJ, et al. Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. J Biol Chem. 2012;287(6):4188-97. Abstract
Labad J, Price JF, Strachan MW, Deary IJ, Seckl JR, Sattar N, et al. Serum leptin and cognitive function in people with type 2 diabetes. Neurobiol Aging. 2012;33(12):2938-2941.e2. Abstract
Drake AJ, McPherson RC, Godfrey KM, Cooper C, Lillycrop KA, Hanson MA, et al. An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth. Clin Endocrinol (Oxf). 2012;77(6):808-15. Abstract
Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012;61(4):790-6. Abstract
van den Driesche S, Walker M, McKinnell C, Scott HM, Eddie SL, Mitchell RT, et al. Proposed Role for COUP-TFII in Regulating Fetal Leydig Cell Steroidogenesis, Perturbation of Which Leads to Masculinization Disorders in Rodents. PLoS ONE. 2012;7(5):e37064. Abstract
Esteves CL, Kelly V, Bégay V, Man TY, Morton NM, Leutz A, et al. Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP. PLoS ONE. 2012;7(5):e37953. Abstract
2011
Drake AJ, Liu L, Kerrigan D, Meehan RR, Seckl JR. Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects. Epigenetics. 2011;6(11). Abstract
Yau JL, Noble J, Seckl JR. 11beta-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control. J Neurosci. 2011;31(11):4188-93. Abstract
Jamieson PM, Cleasby ME, Kuperman Y, Morton NM, Kelly PA, Brownstein DG, et al. Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet. Diabetologia. 2011. Abstract
Man TY, Michailidou Z, Gokcel A, Ramage L, Chapman KE, Kenyon CJ, et al. Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1. Am J Physiol Endocrinol Metab. 2011;300(6):E1076-84. Abstract
Deuchar GA, McLean D, Hadoke PW, Brownstein DG, Webb DJ, Mullins JJ, et al. 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice. Endocrinology. 2011;152(1):236-46. Abstract
Wamil M, Battle JH, Turban S, Kipari T, Seguret D, de Peixoto RS, et al. Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11{beta}-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice. Diabetes. 2011. Abstract
Tang JI, Kenyon CJ, Seckl JR, Nyirenda MJ. Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat. J Hypertens. 2011;29(2):282-9. Abstract
Sai S, Nakagawa Y, Yamaguchi R, Suzuki M, Sakaguchi K, Okada S, et al. Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells. Leuk Res. 2011;35(12):1644-8. Abstract
Drake AJ, Seckl JR. Transmission of programming effects across generations. Pediatr Endocrinol Rev. 2011;9(2):566-78. Abstract
Kirkby NS, Low L, Seckl JR, Walker BR, Webb DJ, Hadoke PW. Quantitative 3-dimensional imaging of murine neointimal and atherosclerotic lesions by optical projection tomography. PLoS ONE. 2011;6(2):e16906. Abstract