Publications

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2012
Coutinho AE, Gray M, Brownstein DG, Salter DM, Sawatzky DA, Clay S, et al. 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. Endocrinology. 2012;153(1):234-40. Abstract
Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012;61(4):790-6. Abstract
Esteves CL, Kelly V, Bégay V, Man TY, Morton NM, Leutz A, et al. Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP. PLoS ONE. 2012;7(5):e37953. Abstract
2011
Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2-13. Abstract
Man TY, Michailidou Z, Gokcel A, Ramage L, Chapman KE, Kenyon CJ, et al. Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1. Am J Physiol Endocrinol Metab. 2011;300(6):E1076-84. Abstract
Deuchar GA, McLean D, Hadoke PW, Brownstein DG, Webb DJ, Mullins JJ, et al. 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice. Endocrinology. 2011;152(1):236-46. Abstract
Wamil M, Battle JH, Turban S, Kipari T, Seguret D, de Peixoto RS, et al. Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11{beta}-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice. Diabetes. 2011. Abstract
Sai S, Nakagawa Y, Yamaguchi R, Suzuki M, Sakaguchi K, Okada S, et al. Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells. Leuk Res. 2011;35(12):1644-8. Abstract
Gambineri A, Tomassoni F, Munarini A, Stimson RH, Mioni R, Pagotto U, et al. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Eur J Endocrinol. 2011;165(2):283-92. Abstract
2010
Yamaguchi R, Nakagawa Y, Liu Y-, Fujisawa Y, Sai S, Nagata E, et al. Effects of maternal high-fat diet on serum lipid concentration and expression of peroxisomal proliferator-activated receptors in the early life of rat offspring. Horm Metab Res. 2010;42(11):821-5. Abstract
Chapman KE, Odermatt A. Steroids: Modulators of inflammation and immunity. J Steroid Biochem Mol Biol. 2010;120(2-3):67-8.
Malavasi EL, Kelly V, Nath N, Gambineri A, Dakin RS, Pagotto U, et al. Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels. Endocrinology. 2010;151(1):195-202. Abstract
Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2010. Abstract
2009
Chapman KE, Coutinho AE, Gray M, Gilmour JS, Savill JS, Seckl JR. The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response. Mol Cell Endocrinol. 2009;301(1-2):123-31. Abstract
Chapman KE, Coutinho AE, Gray M, Gilmour JS, Savill JS, Seckl JR. The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response. Mol Cell Endocrinol. 2009;301(1-2):123-31. Abstract
Kimura A, Stevenson PL, Carter RN, MacColl G, French KL, Paul Simons J, et al. Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity. Eur J Neurosci. 2009;30(2):299-306. Abstract
Sai S, Nakagawa Y, Sakaguchi K, Okada S, Takahashi H, Hongo T, et al. Differential regulation of 11beta-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia. Leuk Res. 2009;33(12):1696-8. Abstract
2008
Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP, et al. Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta. Mol Endocrinol. 2008;22(9):2049-60. Abstract
Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein DG, Owen E, et al. Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008;22:3896-907. Abstract
Ho CK, Nanda J, Chapman KE, Habib FK. Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen. The Journal of endocrinology. 2008;197:483-91. Abstract
Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl JR. 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. Endocrinology. 2008;149(12):5909-18. Abstract
Chapman KE, Seckl JR. 11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function. Neurochem Res. 2008;33(4):624-36. Abstract
Li R-, Nakagawa Y, Liu Y-, Fujisawa Y, Sai S, Nakanishi T, et al. Growth hormone inhibits the 11 beta-Hydroxysteroid dehydrogenase type 1 gene promoter activity via insulin-like growth factor I in HepG2 cells. Horm Metab Res. 2008;40(4):286-8.
De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM. Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo. Endocrinology. 2008;149(4):1861-8. Abstract
De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM. Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo. Endocrinology. 2008;149(4):1861-8. Abstract