Publications

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Journal Article
Wake DJ, Walker BR. 11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Molecular and cellular endocrinology. 2004;215:45-54. Abstract
Jamieson PM, Walker BR, Chapman KE, Andrew R, Rossiter S, Seckl JR. 11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver. The Journal of endocrinology. 2000;165:685-92. Abstract
Hughes KA, Webster SP, Walker BR. 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity. Expert Opin Investig Drugs. 2008;17(4):481-96. Abstract
Sandeep TC, Yau JL, MacLullich AM, Noble J, Deary IJ, Walker BR, et al. 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:6734-9. Abstract
Seckl JR, Walker BR. 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory. Trends in endocrinology and metabolism: TEM. 2004;15:418-24. Abstract
Walker BR, Seckl JR. 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease. Expert opinion on therapeutic targets. 2003;7:771-83. Abstract
Nair S, Lee YH, Lindsay RS, Walker BR, Tataranni PA, Bogardus C, et al. 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Diabetologia. 2004;47:1088-95. Abstract
Christy C, Hadoke PW, Paterson JM, Mullins JJ, Seckl JR, Walker BR. 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids. Hypertension. 2003;42:580-7. Abstract
MacLullich AM, Ferguson KJ, Reid LM, Deary IJ, Starr JM, Wardlaw JM, et al. 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline. Neurobiol Aging. 2010. Abstract
McInnes KJ, Kenyon CJ, Chapman KE, Livingstone DE, Macdonald LJ, Walker BR, et al. 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. The Journal of biological chemistry. 2004;279:22908-12. Abstract
Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. The Journal of clinical endocrinology and metabolism. 2002;87:5587-93. Abstract
Irving RJ, Noon JP, Watt GC, Webb DJ, Walker BR. Activation of the endothelin system in insulin resistance. QJM : monthly journal of the Association of Physicians. 2001;94:321-6. Abstract
Brunner EJ, Hemingway H, Walker BR, Page M, Clarke P, Juneja M, et al. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation. 2002;106:2659-65. Abstract
Stokes J, Walker BR, Campbell JC, Seckl JR, O’Brien C, Andrew R. Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma. Investigative ophthalmology & visual science. 2003;44:5163-7. Abstract
Hadoke PW, Lindsay RS, Seckl JR, Walker BR, Kenyon CJ. Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure. The Journal of endocrinology. 2006;188:435-42. Abstract
McNeilly AD, Macfarlane DP, O'Flaherty E, Livingstone DE, Mitić T, McConnell KM, et al. Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice. J Hepatol. 2010;52(5):705-11. Abstract
Westerbacka J, Yki-Järvinen H, Vehkavaara S, Häkkinen A-, Andrew R, Wake DJ, et al. Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. The Journal of clinical endocrinology and metabolism. 2003;88:4924-31. Abstract
Reynolds RM, Ilyas B, Price JF, Fowkes FG, Newby DE, Webb DJ, et al. Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease. QJM. 2009;102(7):469-75. Abstract
Gambineri A, Tomassoni F, Munarini A, Stimson RH, Mioni R, Pagotto U, et al. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Eur J Endocrinol. 2011;165(2):283-92. Abstract
Mattsson C, Reynolds RM, Simonyte K, Olsson T, Walker BR. Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men. J Clin Endocrinol Metab. 2009;94(4):1347-52. Abstract
Andrew R, Westerbacka J, Wahren J, Yki-Järvinen H, Walker BR. The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes. 2005;54:1364-70. Abstract
Jernigan NL, O’Donaughy TL, Walker BR. Correlation of HO-1 expression with onset and reversal of hypoxia-induced vasoconstrictor hyporeactivity. American journal of physiology. Heart and circulatory physiology. 2001;281:H298-307. Abstract
Rae M, Mohamad A, Price D, Hadoke PW, Walker BR, Mason IJ, et al. Cortisol inactivation by 11beta-hydroxysteroid dehydrogenase-2 may enhance endometrial angiogenesis via reduced thrombospondin-1 in heavy menstruation. J Clin Endocrinol Metab. 2009;94(4):1443-50. Abstract
Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes PC, et al. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans. Diabetes. 2009;58:46-53. Abstract
Reynolds RM, Dennison EM, Walker BR, Syddall HE, Wood PJ, Andrew R, et al. Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women. Calcified tissue international. 2005;77:134-8. Abstract