Publications

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Yau JL, Noble J, Chapman KE, Seckl JR. Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine. Brain research. Molecular brain research. 2004;129:189-92. Abstract
Yamaguchi R, Nakagawa Y, Liu Y-, Fujisawa Y, Sai S, Nagata E, et al. Effects of maternal high-fat diet on serum lipid concentration and expression of peroxisomal proliferator-activated receptors in the early life of rat offspring. Horm Metab Res. 2010;42(11):821-5. Abstract
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Williams LJ, Lyons V, MacLeod I, Rajan V, Darlington GJ, Poli V, et al. C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways. J Biol Chem. 2000;275(39):30232-9. Abstract
Williams LJ, Lyons V, Wallace R, Seckl JR, Chapman KE. CCAAT/enhancer binding protein positively regulates the rat 11 beta-hydroxysteroid dehydrogenase type 1 promoter in liver cells. Biochem Soc Trans. 1997;25(2):235S.
Weaver IC, La Plante P, Weaver S, Parent A, Sharma S, Diorio J, et al. Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Molecular and cellular endocrinology. 2001;185:205-18. Abstract
Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl JR. 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. Endocrinology. 2008;149(12):5909-18. Abstract
Wamil M, Battle JH, Turban S, Kipari T, Seguret D, de Peixoto RS, et al. Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11{beta}-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice. Diabetes. 2011. Abstract
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Voice MW, Seckl JR, Chapman KE. The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites. Gene. 1996;181(1-2):233-5. Abstract
Voice MW, Seckl JR, Edwards CR, Chapman KE. 11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism. Biochem J. 1996;317 ( Pt 2):621-5. Abstract
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Semprini S, Troup TJ, Kotelevtseva N, King K, Davis JR, Mullins LJ, et al. Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic acids research. 2007;35:1402-10. Abstract
Seckl JR, Morton NM, Chapman KE, Walker BR. Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue. Recent progress in hormone research. 2004;59:359-93. Abstract
Seckl JR, Chapman KE. Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase system. Eur J Biochem. 1997;249(2):361-4. Abstract
Seckl JR, Nyirenda MJ, Walker BR, Chapman KE. Glucocorticoids and fetal programming. Biochem Soc Trans. 1999;27(2):74-8.
Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP, et al. Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta. Mol Endocrinol. 2008;22(9):2049-60. Abstract
Sai S, Nakagawa Y, Sakaguchi K, Okada S, Takahashi H, Hongo T, et al. Differential regulation of 11beta-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia. Leuk Res. 2009;33(12):1696-8. Abstract
Sai S, Nakagawa Y, Yamaguchi R, Suzuki M, Sakaguchi K, Okada S, et al. Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells. Leuk Res. 2011;35(12):1644-8. Abstract
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Reynolds RM, Chapman KE, Seckl JR, Walker BR, McKeigue PM, Lithell HO. Skeletal muscle glucocorticoid receptor density and insulin resistance. JAMA : the journal of the American Medical Association. 2002;287:2505-6.
Rajan V, Chapman KE, Lyons V, Jamieson P, Mullins JJ, Edwards CR, et al. Cloning, sequencing and tissue-distribution of mouse 11 beta-hydroxysteroid dehydrogenase-1 cDNA. The Journal of steroid biochemistry and molecular biology. 1995;52:141-7. Abstract
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Nyirenda MJ, Dean S, Lyons V, Chapman KE, Seckl JR. Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the ’foetal origins of hyperglycaemia’? Diabetologia. 2006;49:1412-20. Abstract
Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012;61(4):790-6. Abstract
Napolitano A, Voice MW, Edwards CR, Seckl JR, Chapman KE. 11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated. The Journal of steroid biochemistry and molecular biology. 1998;64:251-60. Abstract
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Mulderry PK, Chapman KE, Lyons V, Harmar AJ. 5'-flanking sequences from the rat preprotachykinin gene direct high-level expression of a reporter gene in adult rat sensory neurons transfected in culture by microinjection. Mol Cell Neurosci. 1993;4(2):164-72. Abstract
Mulderry PK, Dobson SP, Chapman KE, Quinn JP, Lyons V, Morrow JA, et al. Investigation of neuropeptide gene transcription in sensory neurons transfected by microinjection of reporter plasmids. Gene Ther. 1994;1 Suppl 1:S22-3.
Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, et al. Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity. Obesity (Silver Spring). 2007;15(5):1155-63. Abstract
Michailidou Z, Coll AP, Kenyon CJ, Morton NM, O’Rahilly S, Seckl JR, et al. Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone. The Journal of endocrinology. 2007;194:161-70. Abstract