Publications

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Christy C, Hadoke PW, Paterson JM, Mullins JJ, Seckl JR, Walker BR. 11beta-hydroxysteroid dehydrogenase type 2 in mouse aorta: localization and influence on response to glucocorticoids. Hypertension. 2003;42:580-7. Abstract
Deuchar GA, McLean D, Hadoke PW, Brownstein DG, Webb DJ, Mullins JJ, et al. 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice. Endocrinology. 2011;152(1):236-46. Abstract
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Hadoke PW, Lindsay RS, Seckl JR, Walker BR, Kenyon CJ. Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure. The Journal of endocrinology. 2006;188:435-42. Abstract
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Hadoke PW. Cirrhosis of the liver and receptor-mediated function in vascular smooth muscle. Pharmacology & therapeutics. 2001;89:233-54. Abstract
Mills NL, Miller MR, Lucking AJ, Beveridge J, Flint L, Boere JA, et al. Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation. Eur Heart J. 2011;32(21):2660-71. Abstract
Rae M, Mohamad A, Price D, Hadoke PW, Walker BR, Mason IJ, et al. Cortisol inactivation by 11beta-hydroxysteroid dehydrogenase-2 may enhance endometrial angiogenesis via reduced thrombospondin-1 in heavy menstruation. J Clin Endocrinol Metab. 2009;94(4):1443-50. Abstract
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Robertson S, Gray GA, Duffin R, McLean SG, Shaw CA, Hadoke PW, et al. Diesel exhaust particulate induces pulmonary and systemic inflammation in rats without impairing endothelial function ex vivo or in vivo. Particle and Fibre Toxicology. 2012;9(1):9. Abstract
Shaw CA, Robertson S, Miller MR, Duffin R, Tabor CM, Donaldson K, et al. Diesel exhaust particulate--exposed macrophages cause marked endothelial cell activation. Am J Respir Cell Mol Biol. 2011;44(6):840-51. Abstract
Miller MR, Borthwick SJ, Shaw CA, McLean SG, McClure D, Mills NL, et al. Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals. Environmental health perspectives. 2009;117:611-6. Abstract
Tura O, Mills NL, Hadoke PW. Does Bartter's syndrome/Gitelman's syndrome provide a clinical model for investigating the association between calcitonin gene-related peptide and angiotensin II-mediated senescence of endothelial progenitor cells? J Hypertens. 2010;28(10):2170-1; author reply 2171.
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Hadoke PW, Christy C, Kotelevtsev YV, Williams BC, Kenyon CJ, Seckl JR, et al. Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11beta-hydroxysteroid dehydrogenase. Circulation. 2001;104:2832-7. Abstract
Kirkby NS, Hadoke PW, Bagnall AJ, Webb DJ. The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house? Br J Pharmacol. 2008;153(6):1105-19. Abstract
McIntyre CA, Buckley CH, Jones GC, Sandeep TC, Andrews RC, Elliott AI, et al. Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries. British journal of pharmacology. 2001;133:902-8. Abstract
McIntyre CA, Buckley CH, Jones GC, Sandeep TC, Andrews RC, Elliott AI, et al. Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries. Br J Pharmacol. 2001;133(6):902-8. Abstract
Cleary C, Buckley CH, Henry E, McLoughlin P, O’Brien C, Hadoke PW. Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye. The British journal of ophthalmology. 2005;89:223-8. Abstract
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Hadoke PW, McIntyre CA, Gray GA, Buckley CH. Functional heterogeneity of large and small resistance arteries isolated from biopsies of subcutaneous fat: implications for investigation of vascular pathophysiology. Gen Pharmacol. 2000;35(3):119-27. Abstract
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Logie JJ, Ali S, Marshall KM, Heck MM, Walker BR, Hadoke PW. Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration. PLoS ONE. 2010;5(12):e14476. Abstract
Tura O, Crawford J, Barclay GR, Samuel K, Hadoke PW, Roddie H, et al. Granulocyte colony-stimulating factor (G-CSF) depresses angiogenesis in vivo and in vitro: implications for sourcing cells for vascular regeneration therapy. J Thromb Haemost. 2010;8(7):1614-23. Abstract
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Smith LB, Hadoke PW, Dyer E, Denvir MA, Brownstein D, Miller E, et al. Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome. Cardiovasc Res. 2011;90(1):182-90. Abstract
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McSweeney SJ, Hadoke PW, Kozak AM, Small GR, Khaled H, Walker BR, et al. Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11betaHSD1-deficient mice post-MI. Cardiovasc Res. 2010;88(1):159-67. Abstract
Michailidou Z, Turban S, Miller E, Zou X, Schrader J, Ratcliffe PJ, et al. Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. J Biol Chem. 2012;287(6):4188-97. Abstract
Hadoke PW, Macdonald L, Logie JJ, Small GR, Dover AR, Walker BR. Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function. Cellular and molecular life sciences : CMLS. 2006;63:565-78. Abstract
Dover AR, Hadoke PW, Macdonald LJ, Miller E, Newby DE, Walker BR. Intravascular glucocorticoid metabolism during inflammation and injury in mice. Endocrinology. 2007;148:166-72. Abstract
Hadoke PW. Is endothelial progenitor cell senescence a therapeutic target in hypertension? J Hypertens. 2010;28(5):887-8.
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Ramaesh T, Logie JJ, Roseweir AK, Millar RP, Walker BR, Hadoke PW, et al. Kisspeptin-10 inhibits angiogenesis in human placental vessels ex vivo and endothelial cells in vitro. Endocrinology. 2010;151(12):5927-34. Abstract