Publications

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1998
Morton NM, Emilsson V, Liu YL, Cawthorne MA. Leptin action in intestinal cells. The Journal of biological chemistry. 1998;273:26194-201. Abstract
1999
Morton NM, Emilsson V, de Groot P, Pallett AL, Cawthorne MA. Leptin signalling in pancreatic islets and clonal insulin-secreting cells. Journal of molecular endocrinology. 1999;22:173-84. Abstract
2001
Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science (New York, N.Y.). 2001;294:2166-70. Abstract
Morton NM, Holmes MC, Fiévet C, Staels B, Tailleux A, Mullins JJ, et al. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. The Journal of biological chemistry. 2001;276:41293-300. Abstract
2003
Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. The Journal of clinical investigation. 2003;112:83-90. Abstract
2004
Seckl JR, Morton NM, Chapman KE, Walker BR. Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue. Recent progress in hormone research. 2004;59:359-93. Abstract
Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes. 2004;53:931-8. Abstract
Stocker C, O’Dowd J, Morton NM, Wargent E, Sennitt MV, Hislop D, et al. Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2004;28:129-36. Abstract
Morton NM, Ramage L, Seckl JR. Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease. Endocrinology. 2004;145:2707-12. Abstract
Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, et al. Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:7088-93. Abstract
2005
Morton NM, Densmore V, Wamil M, Ramage L, Nichol K, Bünger L, et al. A polygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action. Diabetes. 2005;54:3371-8. Abstract
Drake AJ, Livingstone DE, Andrew R, Seckl JR, Morton NM, Walker BR. Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats. Endocrinology. 2005;146:913-9. Abstract
2006
Goedecke JH, Wake DJ, Levitt NS, Lambert EV, Collins MR, Morton NM, et al. Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women. Clinical endocrinology. 2006;65:81-7. Abstract
Bruley C, Lyons V, Worsley AG, Wilde MD, Darlington GD, Morton NM, et al. A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C/EBPalpha independent. Endocrinology. 2006;147:2879-85. Abstract
Densmore VS, Morton NM, Mullins JJ, Seckl JR. 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia? Endocrinology. 2006;147:4486-95. Abstract
2007
Michailidou Z, Coll AP, Kenyon CJ, Morton NM, O’Rahilly S, Seckl JR, et al. Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone. The Journal of endocrinology. 2007;194:161-70. Abstract
Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, et al. Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity. Obesity (Silver Spring). 2007;15(5):1155-63. Abstract
Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, et al. Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men. The Journal of clinical endocrinology and metabolism. 2007;92:4480-4. Abstract
2008
De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM. Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo. Endocrinology. 2008;149(4):1861-8. Abstract
De Sousa Peixoto RA, Turban S, Battle JH, Chapman KE, Seckl JR, Morton NM. Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo. Endocrinology. 2008;149(4):1861-8. Abstract
Wamil M, Andrew R, Chapman KE, Street J, Morton NM, Seckl JR. 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. Endocrinology. 2008;149(12):5909-18. Abstract
Simoncic M, Horvat S, Stevenson PL, Bünger L, Holmes MC, Kenyon CJ, et al. Divergent physical activity and novel alternative responses to high fat feeding in polygenic fat and lean mice. Behavior genetics. 2008;38:292-300. Abstract
Michailidou Z, Carter RN, Marshall E, Sutherland HG, Brownstein DG, Owen E, et al. Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008;22:3896-907. Abstract
2010
Stimson RH, Lobley GE, Maraki I, Morton NM, Andrew R, Walker BR. Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats. PLoS ONE. 2010;5(1):e8779. Abstract
Macfarlane DP, Zou X, Andrew R, Morton NM, Livingstone DE, Aucott RL, et al. Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency; implications for the pathogenesis of steatohepatitis. Am J Physiol Endocrinol Metab. 2010. Abstract