Publications

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2012
Turban S, Liu X, Ramage L, Webster SP, Walker BR, Dunbar DR, et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism that Prevents High Fat Diet-Induced β-Cell Failure. Diabetes. 2012. Abstract
2010
Sooy K, Webster SP, Noble J, Binnie M, Walker BR, Seckl JR, et al. Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice. J Neurosci. 2010;30(41):13867-72. Abstract
Webster SP, Binnie M, McConnell KM, Sooy K, Ward P, Greaney MF, et al. Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorg Med Chem Lett. 2010;20(11):3265-71. Abstract
Torres-Piedra M, Ortiz-Andrade R, Villalobos-Molina R, Singh N, Medina-Franco JL, Webster SP, et al. A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. Eur J Med Chem. 2010;45(6):2606-12. Abstract
2008
Ortiz-Andrade RR, Sánchez-Salgado JC, Navarrete-Vázquez G, Webster SP, Binnie M, Garc{\'ıa-Jiménez S, et al. Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation. Diabetes, obesity & metabolism. 2008;10:1097-104. Abstract
Moreno-D{\'ıaz H, Villalobos-Molina R, Ortiz-Andrade R, D{\'ıaz-Coutiño D, Medina-Franco JL, Webster SP, et al. Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides. Bioorganic & medicinal chemistry letters. 2008;18:2871-7. Abstract
Hughes KA, Webster SP, Walker BR. 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity. Expert Opin Investig Drugs. 2008;17(4):481-96. Abstract
2007
Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, et al. Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorganic & medicinal chemistry letters. 2007;17:2838-43. Abstract
2006
Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, et al. Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine. Organic & biomolecular chemistry. 2006;4:1209-12. Abstract