<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dempsie, Yvonne</style></author><author><style face="normal" font="default" size="100%">Morecroft, Ian</style></author><author><style face="normal" font="default" size="100%">Welsh, David J</style></author><author><style face="normal" font="default" size="100%">MacRitchie, Neil A</style></author><author><style face="normal" font="default" size="100%">Herold, Nigel</style></author><author><style face="normal" font="default" size="100%">Loughlin, Lynn</style></author><author><style face="normal" font="default" size="100%">Nilsen, Margaret</style></author><author><style face="normal" font="default" size="100%">Peacock, Andrew J</style></author><author><style face="normal" font="default" size="100%">Harmar, Anthony</style></author><author><style face="normal" font="default" size="100%">Bader, Michael</style></author><author><style face="normal" font="default" size="100%">MacLean, Margaret R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.</style></title><secondary-title><style face="normal" font="default" size="100%">Circulation</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Circulation</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Anoxia</style></keyword><keyword><style  face="normal" font="default" size="100%">Dexfenfluramine</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension, Pulmonary</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Transgenic</style></keyword><keyword><style  face="normal" font="default" size="100%">p38 Mitogen-Activated Protein Kinases</style></keyword><keyword><style  face="normal" font="default" size="100%">Serotonin</style></keyword><keyword><style  face="normal" font="default" size="100%">Serotonin Plasma Membrane Transport Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Serotonin Receptor Agonists</style></keyword><keyword><style  face="normal" font="default" size="100%">Tryptophan Hydroxylase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008 Jun 3</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">117</style></volume><pages><style face="normal" font="default" size="100%">2928-37</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the &quot;serotonin hypothesis&quot; of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains controversial. Here, we used novel transgenic mice lacking peripheral serotonin (deficient in tryptophan hydroxylase-1; Tph1(-/-) mice) or overexpressing the gene for the human serotonin transporter (SERT; SERT(+) mice) to investigate this further.</style></abstract><issue><style face="normal" font="default" size="100%">22</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/18506000?dopt=Abstract</style></custom1></record></records></xml>