BHF Centre for Vascular Regeneration

BHF Centre for Vascular Regeneration

The British Heart Foundation Centre for Vascular Regeneration (CVR) provides cohesion between the very best basic, translational and clinical vascular scientists in order to identify the optimal approaches to vascular repair and regeneration with rapid translation into the clinic. 

We aim to:

  1. explore vascular cell lineages, and their derivation and differentiation including investigation of complementary and synergistic gene therapy and micro-RNA (miRNA) based approaches, (ii) develop tissue engineering to enhance macrovessel formation and function
  2. test potential therapeutic strategies in relevant pre-clinical models
  3. develop imaging strategies to track transplanted cells and define efficacy and safety of interventions
  4. conduct early phase clinical trials. These approaches will be developed in parallel such that both early pre-clinical and clinical models can be established in order that the most promising therapies and techniques can be rapidly and efficiently translated into the clinic.

To achieve this, we utilise cutting-edge techniques and technologies to develop and produce relevant cell types at high purity and quality with strategies relevant for scale up and good manufacturing practice (GMP) compliance. We identify the optimal stem or progenitor cell source for therapy, and facilitate tissue bioengineering for applications in rodent and large animal models of ischaemia. At the clinical interface, we conduct early phase clinical trials of adipose tissue-derived pericytes in order to validate the methodology to track and quantify cell engraftment and reparative neovascularisation in patients with critical limb ischaemia and potentially those with acute myocardial infarction. In the longer term, this will enable us to establish the regulatory and clinical pathways for broad application to future regenerative medicine trials that will arise from the basic and translational findings that are generated from within our Centre.

CVR Members

Andrew Baker

Andrew H Baker, University of Edinburgh

Andrew H Baker, University of Edinburgh

Mairi Brittan

Mairi Brittan, University of Edinburgh

Mairi Brittan, University of Edinburgh

Andrea Caporali

Andrea Caporali, University of Edinburgh

Andrea Caporali, University of Edinburgh

Massimo Caputo

Massimo Caputo, University of Bristol

Mihaela Crisan

Mihaela Crisan, University of Edinburgh

Mihaela Crisan, University of Edinburgh

Iain Dykes

Iain M Dykes, University of Bristol

Iain M Dykes, University of Bristol

Georgina Ellison

Georgina M Ellison, King's College London

Gillian A Gray

Gillian A Gray, University of Edinburgh

Gillian A Gray, University of Edinburgh

Patrick WF Hadoke

Patrick WF Hadoke, University of Edinburgh

Patrick WF Hadoke, University of Edinburgh

Paolo Madeddu

Paolo Madeddu, University of Bristol

Manuel Mayr

Manuel Mayr, King's College London

Nicholas L Mills

Nicholas L Mills, University of Edinburgh

Nicholas L Mills, University of Edinburgh

Jo Mountford

Jo Mountford, University of Glasgow

David E Newby

David E Newby, University of Edinburgh

David E Newby, University of Edinburgh

Qingbo Xu

Qingbo Xu, King's College London