| Title | The alpha 2-adrenoceptor antagonist SK&F 104078 has high affinity for 5-HT1A and 5-HT2 receptors. |
| Publication Type | Journal Article |
| Year of Publication | 1989 |
| Authors | Kilpatrick AT, Brown CM, Mackinnon AC, Spedding M |
| Journal | European journal of pharmacology |
| Volume | 166 |
| Issue | 2 |
| Pagination | 315-8 |
| Date Published | 1989 Jul 18 |
| ISSN | 0014-2999 |
| Keywords | 8-Hydroxy-2-(di-n-propylamino)tetralin, Adrenergic alpha-Antagonists, Animals, Benzazepines, Binding, Competitive, Cerebral Cortex, Ketanserin, Male, Rats, Rats, Inbred Strains, Receptors, Adrenergic, alpha, Receptors, Serotonin, Tetrahydronaphthalenes |
| Abstract | The affinity of SK&F 104078, a putative selective postjunctional alpha 2-adrenoceptor antagonist, was determined at 5-HT1A and 5-HT2 receptors in rat brain. SK&F 104078 had moderate affinity towards alpha 2-adrenoceptors (pKi 6.7) but displayed higher affinity at 5-HT1A (pKi 8.1) and 5-HT2 (pKi 7.6) receptors. If SK&F 104078 is used in functional studies to define heterogeneity within of alpha 2-adrenoceptors, care must be taken to define the role of 5-HT1A and 5-HT2 receptors in the response being measured. |
| Alternate Journal | Eur. J. Pharmacol. |
