| Title | Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Anderson JA, Hirsh J, Yusuf S, Johnston M, Afzal R, Mehta SR, Fox KA, Budaj A, Eikelboom JW |
| Journal | Journal of thrombosis and haemostasis : JTH |
| Volume | 8 |
| Issue | 2 |
| Pagination | 243-9 |
| Date Published | 2010 Feb |
| ISSN | 1538-7836 |
| Keywords | Acute Coronary Syndrome, Aged, Anticoagulants, Blood Coagulation, Dose-Response Relationship, Drug, Double-Blind Method, Drug Monitoring, Enoxaparin, Factor Xa, Hemorrhage, Humans, Injections, Subcutaneous, Middle Aged, Partial Thromboplastin Time, Platelet Aggregation Inhibitors, Polysaccharides, Recurrence, Risk Assessment, Risk Factors, Thrombin, Time Factors, Treatment Outcome |
| Abstract | In the OASIS-5 trial, fondaparinux reduced major bleeding with similar short-term efficacy as enoxaparin but lowered death and stroke during long-term follow-up. The mechanism of lower bleeding and improved efficacy with fondaparinux is uncertain. |
| Alternate Journal | J. Thromb. Haemost. |
