| Title | Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Dempsie Y, Morecroft I, Welsh DJ, MacRitchie NA, Herold N, Loughlin L, Nilsen M, Peacock AJ, Harmar A, Bader M, MacLean MR |
| Journal | Circulation |
| Volume | 117 |
| Issue | 22 |
| Pagination | 2928-37 |
| Date Published | 2008 Jun 3 |
| ISSN | 1524-4539 |
| Keywords | Animals, Anoxia, Dexfenfluramine, Hypertension, Pulmonary, Mice, Mice, Transgenic, p38 Mitogen-Activated Protein Kinases, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Receptor Agonists, Tryptophan Hydroxylase |
| Abstract | The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the "serotonin hypothesis" of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains controversial. Here, we used novel transgenic mice lacking peripheral serotonin (deficient in tryptophan hydroxylase-1; Tph1(-/-) mice) or overexpressing the gene for the human serotonin transporter (SERT; SERT(+) mice) to investigate this further. |
| Alternate Journal | Circulation |
| Refereed Designation | Refereed |
