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Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury.

TitleNitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury.
Publication TypeJournal Article
Year of Publication2010
AuthorsWegiel B, Gallo DJ, Raman KG, Karlsson JM, Ozanich B, Chin BY, Tzeng E, Ahmad S, Ahmed A, Baty CJ, Otterbein LE
JournalCirculation
Volume121
Issue4
Pagination537-48
Date Published2010 Feb 2
ISSN1524-4539
KeywordsAnimals, Aorta, Bone Marrow Transplantation, Carbon Monoxide, Carotid Artery Injuries, Cell Movement, Cell Proliferation, Cells, Cultured, Endothelium, Vascular, Hematopoietic Stem Cells, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Nitric Oxide, Nitric Oxide Synthase Type III, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Retinoblastoma Protein, rhoA GTP-Binding Protein
AbstractCarbon monoxide (CO) has emerged as a vascular homeostatic molecule that prevents balloon angioplasty-induced stenosis via antiproliferative effects on vascular smooth muscle cells. The effects of CO on reendothelialization have not been evaluated.
Alternate JournalCirculation
Refereed DesignationRefereed