| Title | Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats. |
| Publication Type | Journal Article |
| Year of Publication | 1994 |
| Authors | Whitworth CE, Fleming S, Cumming AD, Morton JJ, Burns NJ, Williams BC, Mullins JJ |
| Journal | Kidney international |
| Volume | 46 |
| Pagination | 1528-32 |
| Date Published | 1994 Dec |
| Abstract | Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension. |
