Vascular injury & repair

Cardiovascular disease remains the biggest single cause of death and disability in many countries, accounting for 160,000 deaths each year in the UK, 42,000 of which occur in people below the age of 75. However, an improved understanding of cardiovascular disease has led to better treatments, with death rates in the UK declining by more than three quarters in the last 50 years.


Lipid droplets in zebrafish

The Metabolism Theme  brings together clinical and basic scientists with an interest in the physiology and pathophysiology of metabolic processes relevant to obesity, diabetes and cardiovascular disease. This covers development, genetics and epigenetics, mature function and pathogenesis, through to regeneration and transplant of organs that are central to metabolic homeostasis: adipose, liver, heart, pancreatic islets and lymphoid.

Brain & Body

The Brain & Body Theme aims to advance the understanding of relations between the brain and body in health and cardiometabolic disease. Clinical and basic scientists in this evolving multidisciplinary group come together to study the interaction of genetic and environmental factors (eg. Stress), throughout the lifecourse, on brain microstructure and function and the consequent effects on major organs of the body relevant to cardiometabolic disease.

Renal & Hypertension

High blood pressure is the major risk factor driving the global crisis of non-communicable disease, chiefly Cardiovascular Disease and Chronic Kidney Disease. These diseases reduce the quality of life for millions of people and the medical care is costly. Cardiovascular disease is the leading cause of death worldwide: patients with kidney disease are more likely to die of a cardiovascular complication than progress to renal failure. The Renal and Hypertension theme focusses research on these global health challenges.

Early Life

The Early Life Theme brings together clinical and basic scientists with an interest in understanding the mechanisms underlying the developmental origins of health and disease. Our research is translational – from bench to bedside and back – and covers experimental studies in animal and cellular models, through to detailed physiological clinical studies in humans across the lifespan, and making use of the ‘big data’ available in Scotland.