I undertook my PhD in the Genetics of Diabetic Kidney Disease in Queen's University Belfast in 2003, and then trained in Nephrology in both Belfast and Edinburgh. I was awarded an MRC Clinician Scientist Fellowship in 2007 and moved to the Centre for Inflammation Research (CIR) in the University of Edinburgh to investigate the role of inflammation in the pathogenesis of diabetic nephrology. I have recently received a BHF Transition Fellowship Award and I am curently embedded in Prof John Mullins group within the CVS. I also work part-time as an Honorary Consultant Nephrologist in the Royal Infirmary, Edinburgh
Diabetic kidney disease is the single most common cause of end-stage renal disease in the Western world, accounting for 20% of all incident cases of dialysis in the UK and up to 50% in the US. I am interested in dissecting the pathogenesis of diabetic nephropathy combining novel rodent models and unbiased gene expression analysis. Good blood sugar and blood pressure control can result in regression of nephropathy in patients with diabetes and I am particularly interested in dissecting the mechanisms by which this may occur. I collaborate closely with Prof John Mullins, Dr Donald Dunbar and Dr James Dear from the CVS and Dr Jeremy Hughes from the CIR.
The recent increase in the incidence of diabetic nephropathy is largely driven by the epidemic of obesity, therefore I also have developed an interest in the pathogenesis of obesity and type 2 diabetes in collaboration with with Dr Nik Morton.