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Marc Dweck

Profile

on
Title: 
Dr
Marc
Dweck
Admin unit: 
Cardiology
Job title: 
BHF Intermediate Clinical Research Fellow
Contact email: 
marc.dweck@ed.ac.uk
Telephone: 
0131 242 1779
Room: 
SU305
Location: 
Chancellor's Building

Research

Background: 

Dr Marc Dweck went to the University of Edinburgh Medical School between 1997 and 2003. He graduated with 1st class honours in his Medical Sciences BSc and with MBChB. He performed his medical training at the Hammersmith, St Thomas' and the Royal Brompton hospitals before returning to Edinburgh for Cardioloigy Specialist Registrar training in 2007. Marc is training in cardiac device implantation and non-invasive cardiac imaging, having performed imaging fellowships at Cedars Sinai Hospital, Los Angeles and the Royal Brompton CMR unit. Marc is fully  accredited in echocardiography, cardiac CT and cardiovascular MRI.  He completed his PhD under the supervision of Prof David Newby, Dr James Rudd (Cambridge) and Dr Nicholas Boon and has been appointed as a British Heart Foundation Clinical Lecturer here in Edinburgh, a Fellow of the American College of Cardiology and as a member of the Young Academy of Scotland. More recently he was awarded a Intermediate Clinical Research Fellowship by the British Heart Foundation during which he will spend a year at Mount Sinai Hospital in Translational Molecular Imaging Institute under the supervision of Professors Zahi Fayad and Valentin Fuster. 

His research interests are in the use of modern non-invasive imaging techniques to study cardiovascular disease in particular coroanry atherosclerosis and aortic stenosis. He has published in the world's leading general medical and cardiology journals  and has been awarded the following prizes

  • Glaxo-Smith Kline Emerging Scientist of the Year, Academy of Pharmaceutical Science 2014
  • BMJ Awards, UK Research Paper of the Year, Runner up 2014. 
  • Rising Star Award, University of Edinburgh 2014 
  • Patrick Neil Medal. Early Career Award for Life Sciences, The Royal Society, Edinburgh
  • Finalist The Lancet Prize, Academy of Medical Sciences 2013 
  • Winner Best Poster, American College of Cardiology Scientific Sessions 2013
  • William W Parmley Young Author Award. Journal of the American College of Cardiology 2012
  • Winner Young Investigator Award, American College of Cardiology, Chicago 2012
  • President's Medal, Royal Society of Medicine 2012
  • Young Research Worker's Prize, Radiology Society of North America, Chicago 2011
  • Gold-medal for best abstract at EUROCMR, Florence 2010

 

Research interests: 

I am interested in the use of modern imaging techniques to investigate the pathophysiology of aortic stenosis. Primarily combined positron emission tomography and computed tomography (PET/CT) to study inflammation and calcification within the valve and cardiovascular magnetic resonance (CMR) to study fibrosis both within the valve and the hypetrophied myocardium. These studies form the basis of my British Heart Foundation Clinical PhD training fellowship FS/10/026 and my recent Intermediate Clinical Research Fellowship (FS/14/78/31020). More recently I have become interested in the application of PET/CT to the detection of high-risk atherosclerotic plaque that has led to major funding investigating whether 18F-Fluoride can improve the prediction of myocardial infarction (WT103782AIA). 

 

Research images: 
18F NaF uptake in the proximal left anterior descending coronary artery
18F-NaF uptake in the valve of a patient with aortic stenosis
Examples of mid-wall late gadolinium enhancement in patients with aortic stenosis

Grants

Funding body Principal grant holder Title Start date End date Amount
1 British Heart Foundation Marc Dweck Modification of calcification activity and 18F-Fluoride positron emission tomography uptake in cardiovascular disease. 01/12/2014 01/12/2019 976514
2 British Heart Foundation Marc Dweck An intermediate clinical research fellowship in cardiovascular non-invasive molecular imaging 01/12/2014 30/11/2019 976514
3 British Heart Foundation Marc Dweck 18F-fluoride in the identification of bioprosthetic valve degeneration following surgical and transcatheter implantation. 01/08/2014 31/07/2017 294956
4 Wellcome Trust David Newby Identification and prediction of coronary artery plaque rupture using 18F-fluoride psitron emission tomorgraphy 01/08/2014 31/07/2019 2334774
5 Chief Scientist Office Jennifer Richards 18F-Sodium fluoride imaging of abdominal aortic aneurysms 01/07/2014 30/06/2017 254663
6 British Heart Foundation Nicholas Cruden Development of a clinical translational model of arterial injury and repair to assess vascular stem cell therapies. 05/08/2013 04/08/2015 299405
7 Scottish Office David Newby Identification of cellular inflammation in the myocardium using magnetic resonance imaging 01/06/2013 31/07/2014 211771
8 Chest, Heart & Stroke Scotland Scott Semple Metabolic Imaging in Carotid, Atherosclerosis (MICA Study) 01/12/2012 31/07/2015 50722
9 Chief Scientist Office Marc Dweck Identification of Cellular Inflammation in the Myocardium using Magnetic Resonance Imaging 01/08/2012 01/08/2015 264714
10 British Heart Foundation David Newby Role of 18F-Fluoride Imaging as a Novel Marker of Plaque Instability - The MICA Study (Molecular Imaging in Carotid Atherosclerosis) 01/08/2012 31/07/2014 251525